When departing from Beaufort, wait for a northwest front to come through. Take off at the top of the tide and head south, paralleling Cape Lookout shoals. Once clear of the shoals, head east/southeast (until the butter melts, as they say), then turn south to the islands. Usually the northwester will blow you across the Stream; then the wind will clock north to northeast, all favorable on your east/southeast course. Sometimes the northeast wind will carry you down to the trades, providing you with wind all the way to your destination. Early in the passage, its important to work your way as far east as practical before you hit the trades farther south, which in my experience tend to blow from the east, east-southeast, or southeast in November.